Bioinformatician, Barcelona Barcelona Spain

Bioinformatician, Barcelona Barcelona Spain




Bioinformatician, Barcelona Barcelona Spain

Detalles de la oferta

You are here: Home > Bioinformatician in the Single Cell Epigenomics and Cancer Development LabBioinformatician in the Single Cell Epigenomics and Cancer Development LabBioinformatician in the Single Cell Epigenomics and Cancer Development LabThe InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG shares principles of an interdisciplinary, motivated and creative scientific team that is supported by high-end and innovative technologies and a flexible and efficient administration.We are looking for an enthusiastic and motivated bioinformatician to join the Single Cell Epigenomics and Cancer Development team to provide support in creating a better understanding of early tumour formation. The candidate will lead the data analysis of different single-cell technology-based projects and will also provide bioinformatics support to other team members in the lab, both at the level of experimental design and data analysis.The layers that we AM to address in the lab at the single-cell level comprise gene expression, chromatin accessibility, DNA methylation and somatic mutations.About the labTumours originate from normal cells that acquire tumour-initiating genetic events, such as translocations and somatic mutations. These genetic hits turn normal cells into pre-malignant cells, but do not lead to immediate tumour formation. For that, secondary genetic events as well as epigenetic hits are required.We AM to create a better understanding of how epigenetic tumour-associated changes arise in the context of non-Hodgkin lymphomas. To that end, we AM to study the occurrence of these changes in healthy individuals as well as in pre-malignant cells in vitro (to be created by CRISPR/Cas9 genomic editing) and in vivo using single-cell technologies. On top of that, we AM to define cell intrinsic mechanisms, such as enhancer activation and 3D chromatin interactions, that influence the occurrence of the observed changes.We are affiliated to the Gene Regulation, Stem Cell and Cancer Research program of the CRG in double affiliation with the Centre for Genomic Analysis (CNAG-CRG) and the department of Oncology and Haematology of the IDIBAPS. We strongly believe that bringing the knowledge and resources of these different environments together majorly aids to better understand the biology of disease. Further information can be found at: () .Whom would we like to hireProfessional experienceMust HaveYou have good knowledge of Computational BiologyYou have at least 5 years of experience in performing bioinformatics analysisYou have a strong background in analysis of single-cell technology-based dataDesirable but not required/ Nice to haveYou have experience in data analysis of genetic layers, epigenetic data (e.g. ChIP-seq, ATAC-seq, DNA methylation data, chromatin conformation capture data) and RNA-seqYou hold a PhD degree in BioinformaticsEducation and trainingYou hold a masters degree in Bioinformatics or a related discipline.LanguagesYou have fluency in EnglishTechnical skillsYou have high level of hands-on experience in:NGS data-analysisSingle-cell technology-based data analysisYou have advanced Unix operating systems skillsYou are competent in Python, Perl or RCompetencesYou have highly developed organization skillsYou have excellent analytical and problem-solving skillsYou have enthusiasm, motivation and dedication to explore new scientific avenuesYou have capability to work on different projects simultaneously as part of a team and/or independently Working ConditionsContract duration: 1.5 year with possibility of extensionEstimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section .We offer and promote a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, race, religion or sexual orientation.The CRG is committed to reconcile a work and family life of its employees and are offering extended vacation period and the possibility to benefit from flexible working hours.Application ProcedureAll applications must include:Contact details of two referees.All applications must be addressed to Dr. Renée Beekman and be submitted online through the "Apply" button below.Selection ProcessPre-selection: The pre-selection process will be based on qualifications and expertise reflected on the candidates CVS. It will be merit-based.Interview: Preselected candidates will be contacted to coordinate an interview with the PI.Offer Letter: Once the successful candidate is identified the Human Resources department will send a Job Offer, specifying the start day, salary, working conditions, among other important details.Deadline: Please submit your application by May 29 th ,

Fuente: Jobsora




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