.The role of the postdoc to be hired will be to contribute to the characterization of molecular mechanisms of AS regulation, including the identification and analysis of small molecule modulators and their possible applications in medicine.About the team The group of Juan Valcárcel at the Center for Genomic Regulation (CRG) of Barcelona has a long trajectory studying pre-mRNA splicing regulation. The group combines high-throughput methods with detailed biochemical and cellular assays and collaborates closely with other groups working on computational and structural biology to study molecular mechanisms and networks of alternative splicing regulation in cancer. The group also develops mechanism-based novel therapeutic approaches for oncology.Juan Valcárcel obtained his PhD from work on influenza virus splicing regulation carried out in the lab of Juan Ortín at the Center of Molecular Biology Severo Ochoa in Madrid. After a postdoc with Michael Green at the University of Massachusetts, working on mechanisms of splice site recognition and regulation, he established his group at the European Molecular Biology Laboratory (EMBL) in Heidelberg in 1996. In 2002 the group moved to the newly created Center for Genomic Regulation (CRG) of Barcelona. He is a Research Professor of the Catalonian Institute for Research and Advanced Studies (ICREA) and associated Professor of the University Pompeu Fabra. Elected EMBO member in 2004, he was Deputy Coordinator of the European Alternative Splicing Network of Excellence and Coordinator of the RNAREG Consolider consortium, the European Innovation Council-funded TAONas-LUAD and the Eurpean Research Council-funded UNLEASH projects. He is member of the Editorial Board of the Journals Molecular Cell,RNA and Molecular and Cellular Biology as well as of the Scientific Advisory Boards of several Research Institutes and companies in Europe and USA. He served as President of the RNA Society in 2017-2018 and as Past-President in 2019-2020. Our team is currently composed of 2 technicians, 1 lab manager, 2 PhD students, 5 postdocs and 1 Staff Scientist.Whom would we like to hire? Professional experience Must Have You have a PhD in Molecular BiologyYou have proven experience in Molecular Biology and Gene RegulationYou are fluent in EnglishDesirable but not required/ Nice to have Computational Biology SkillsExperience with RNA analysisEducation and training You hold a PhD in Molecular Biology Languages You are proficient in EnglishTechnical skills You have advanced MS Office skills.... Competences Highly developed organizational skillsIndependenceProfessional ambitionCapacity for team work The Offer – Working Conditions Contract duration: up to 4 yearsEstimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scalesTarget start date: September 2024We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities
