Your mission The Josep Carreras Leukaemia Research Institute (IJC) is a non-profit research institute based in Barcelona dedicated to advancing the understanding of leukemia and related disorders, in collaboration with the University of Barcelona and the Autonomous University of Barcelona. The IJC has laboratories in 5 clinical campuses: i) Hospital Clínic, ii) Hospital de Sant Pau and iii) Hospital Germans Trias Pujol iv) Hospital del Mar and v) Hospital Josep Trueta Girona. IJC serves as a collaborative center for basic researchers and physicians to work together on fundamental clinical and biological aspects of leukemia. The IJC offers an excellent work environment based on a multidisciplinary fusion of state-of-the-art ideas and facilities. We are looking for a highly motivated L aboratory Technician to work in the fields of epigenetics, aging, and cancer through the study of the family of NAD+-dependent enzymes, named Sirtuins. The successful candidate has the opportunity to build her/his professional skills at the intersection of distinct fields, including epigenetics, aging and immunology. Her/his work will help in advancing the development of new therapeutic strategies to delay the onset of aging and the development of aging-related diseases and cancer. Among them, these strategies may have a strong impact in leukemia treatment. Responsibilities: Study the SIRT7-NPM-c-Myc regulatory axis in lung cancer cells and mouse tumors through a combination of biochemistry, molecular biology, genomics, proteomics, and cell biology. Analyze the contribution of SIRT7 to NPM and Myc genomic distribution through ChIPseq and RNAseq analysis in cancer cells. Maintenance and handling of the SIRT7-KO mouse colony. Your profile BSc in Biology, Biomedicine, or similar. A high level of motivation and interest. Accreditation and Experience working with mice Expertise in molecular Biology, cell biology and FACs Expertise working with protein-related techniques Expertise in genomic and proteomic studies Previous experience working with Sirtuins will be positively considered Good level of oral and written English. Why us? A temporary contract for 1 year ( Indefinido por actividades científico-técnicas) The contract is linked to the project Role of the SIRT7-NPM-c-Myc pathway in lung cancer. Full-time contract. Competitive salary to be defined depending on candidate experience. The opportunity to contribute to cutting-edge translational research projects in the stimulating environment of the Josep Carreras Leukaemia Research Institute. Deadline Please submit your application by 30th, April 2024 About us What makes us different? Our mission is to investigate the epidemiological, preventive, clinical, translational, and basic aspects of leukaemia and other hematologic malignancies through innovat ion to cure them. The vision of the Josep Carre ras Leukaemia Research Institute is to be a world-class reference and excellent research multicampus that contributes to the improvement of results, and the cure of patients affected by leukemia and other malignant hemopathies, through innovation, sustainability, social responsibility, talent, and professional experience. HR Excellence The European Commission awarded the IJC the HR Excellence seal in July 2019. The IJC continues to work to maintain its policies in line with the Charter and Code principles. This recognition reflects our commitment to continuously improving our human resources policies in line with the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers. The HRS4R has the main objective of ensuring that research centers of excellence implement and respect the requirements of the European Charter for Researchers and the Code of Conduct for hiring researchers (from here on referred to as the Charter and Code) within their human resources policies. This EC initiative aims to promote training, professional development, and mobility for all European scientists. The IJC supports these values and principles, which will not only serve to strengthen its internal policies but will actively stimulate excellent research and firmly situate the organization as an institution with a stimulating working environment that favors the development of its scientists. IJC is an equal-opportunity employer. We evaluate qualified applicants without regard to race, color, religion, sex, national origin, disability, and other legally protected characteristics
